In studies with oral contraceptives (birth control pills) containing estrogens, cigarette smoking during the use of estrogens was shown to cause an increased risk of serious side effects affecting the heart or blood circulation, such as dangerous blood clots, heart attack, or stroke. The risk increased as the amount of smoking and the age of the smoker increased. Women aged 35 and over were at greatest risk when they smoked while using oral contraceptives containing estrogens. It is not known if this risk exists with the use of androgens and estrogens for symptoms of menopause. However, smoking may make estrogens less effective.
Winstrol also does a very good job of reducing the amount of SHBG in the body, thus allowing other steroids to be much more abundant in their free state in the body. Due to this fact, Stan makes a great addition to all cycles. Winstrol is a C17-alpha alkylated compound, and therefore can be toxic to the liver over time. Because of this, it is recommended that bodybuilders using this compound try to keep dosage in a reasonable range and limit cycle duration to 10wks. There are also several liver protectants and detoxifiers available which should be considered when doing a cycle of this steroid.