Temovate Cream or Ointment is applied topically (on the skin) to the affected areas twice daily. Treatment should be limited to 2 consecutive weeks and amounts greater than 50 g/week should not be used. Temovate may interact with corticosteroids taken by mouth or drugs that lower the immune system . Tell your doctor about all medications you are taking. During pregnancy, Temovate should be used only when prescribed. It is not known whether this drug passes into breast milk when applied to the skin. Similar medications pass into breast milk when taken by mouth. Consult your doctor before breastfeeding.
Fluticasone propionate is metabolized in the liver by cytochrome P450 3A4-mediated hydrolysis of the 5fluoromethyl carbothiolate grouping. This transformation occurs in 1 metabolic step to produce the inactive 17β-carboxylic acid metabolite, the only known metabolite detected in man. This metabolite has approximately 2000 times less affinity than the parent drug for the glucocorticoid receptor of human lung cytosol in vitro and negligible pharmacological activity in animal studies. Other metabolites detected in vitro using cultured human hepatoma cells have not been detected in man.